Document Details

Document Type : Project 
Document Title :
Identification of mutations in FLT3 gene in patients with acute myeloid leukemia in Saudi Arabia
التعرف على الطفرات الجينية في FLT3 جين في مرضى سرطان الدم في المملكة العربية السعودية
 
Subject : Medical Technology 
Document Language : Arabic 
Abstract : The acute leukaemias are defined as malignancies of immature hematopoietic cells and are divided into two main groups: acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL). By definition AML has >30% blast cells in the bone marrow, although in patients with a high level of circulating white blood cells (e.g. >50109/L), the diagnosis is self-evident from the peripheral blood. Several studies suggest that mutations in hematopoietic growth factor (HGF) receptors in myeloid leukemia may lead to activation of the receptor in the absence of specific ligand. Leukemogenesis is believed to result from a multi-step process while may include gene activation and/or inactivation associated with deregulated gene expression, gene rearrangements, and/or point mutations. Receptor Tyrosine kinases (RTK) are a group HGF receptors. FLT3 proto-oncogene (fms-like tyrosine kinase), is a member of the class III RTK family that is a member of the same family as PDGF, c-fms and c-kit. FLT3 and its ligand play an important role in the early events of hematopoietic stem cell proliferation and differentiation. The main aim of this project is to determine the frequency of the FLT3 proto-oncogene mutations in acute myeloid leukemia (AML) patients in Saudi Arabia. 
Publishing Year : 1425 AH
2005 AD 
Sponsor Name : kau 
Sponsorship Year : 1425 AH
2005 AD 
Added Date : Saturday, November 7, 2009 

Researchers

Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
عبدالله ممدوح قاريGari, abd-allah MamdoohInvestigatorDoctorate 

Files

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 24392.doc doc 

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